Teamwork by IL ‐10+ and IL ‐35 + T regs
نویسندگان
چکیده
منابع مشابه
Effect of interleukin (IL)-35 on IL-17 expression and production by human CD4+ T cells
BACKGROUND Interleukin (IL)-17 produced by mainly T helper 17 (Th17) cells may play an important destructive role in chronic periodontitis (CP). Thus, anti-inflammatory cytokines, such as IL-35, might have a beneficial effect in periodontitis by inhibiting differentiation of Th17 cells. Th17 differentiation is regulated by the retinoic acid receptor-related orphan receptor (ROR) α (encoded by R...
متن کاملIL-6, IL-10 and IL-17 Gene Polymorphisms in Iranian Women with Recurrent Miscarriage
Background: Pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (RM). Objective: To investigate the association between RM and five polymorphisms of cytokine genes, interleukin 10 (IL-10), (-592 A/C, -819 C/T, -1082 A/G), IL-6 (-174 C/G) and IL-17 (-197 G/A) in Iranian women. Method: Po...
متن کاملتنظیم سلول های t خون بندناف انسان توسط سایتوکاین خانواده (il-10 (il-22و سایتوکاین خانواده (ifn-λ (il-28a
طی ده سال گذشته، خون بندناف به عنوان یک منبع جایگزین برای بدست آوردن سلولهای خونساز، در پیوند آلوژنیک مورد توجه قرار گرفته است .از مزایای خون بند ناف سهل الوصول بودن آن بوده و همچنین کم بودن سلولهای t در این نمونه می باشد . از طرفی اکثر سلولهای t موجود نیز مبتدی می باشند. همین ویژگی باعث می شود تا در استفاده از این سلولها برای پیوند مغز استخوان کمتر شاهد بروز بیماری پیوند علیه میزبان در گیرندگا...
15 صفحه اولCloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9.
IL-9 is a Th2 cytokine active on various cell types such as T and B lymphocytes, mast cells, and eosinophils, and potentially involved in allergy and asthma. To understand better the molecular mechanisms underlying the activity of this cytokine, we used a cDNA subtraction method to identify genes specifically induced by IL-9 in mouse T cells. One of the IL-9-regulated genes isolated by this app...
متن کاملRegulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner.
Regulatory T cells (T(reg)) are believed to suppress conventional T cell (T(conv)) proliferation in vitro in a contact-dependent, cytokine-independent manner, based in part on experiments in which T(reg) and T(conv) are separated by a permeable membrane. We show that the production of IL-35, a novel inhibitory cytokine expressed by natural T(reg), increases substantially following contact with ...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2019
ISSN: 1600-6135,1600-6143
DOI: 10.1111/ajt.15511